Cardiac toxicity

Cardiotoxicity is becoming one of the most important complications of drug development and their treatments. Cardiac toxicity represents a new development or a worsening of arrhythmias in patients with or without clinical symptoms. The following markers recommended by Predictive Safety Testing Consortium can be assayed in addition to traditional toxicity markers:

Natriuretic Peptides (NPs), LDH, CK isozymes, AST, SGOT, myoglobin, myosin, cardiolipin, Troponins (TIC)

Mechanistic toxicology

To understand mechanism of action, the following assay end points are offered by Drik:

Cell viability

• MTT
• Neutral red
• LDH

Cell death

• Propidium iodide
• Fluorojade B